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Injections like HCG (Human Chorionic Gonadotropin) are sometimes used to treat underlying causes in men but can actually cause breast tenderness or swelling as a side effect. Comparison of Treatment Options Gynecomastia (Male Breast Reduction) |Bumrungrad Hospital

In cases where gynecomastia is caused by severe testosterone deficiency, testosterone replacement therapy (TRT) injections may be used to rebalance the body's hormone levels.

If you have already had surgery and are dealing with firm lumps, Kenalog-10 is often the "real" injection doctors turn to.