If the game crashes before the main menu, go to Documents > Capcom > Resident Evil 6 and open config.ini . Find VSYNC and set it to OFF .
Some antivirus programs block the game from reading its own files. Add the Resident Evil 6 folder to your Windows Security exclusions. resident evil 6 fatal error failed open file
If the error mentions a specific path like nativePC\shader , the desktop shortcut might be pointing to the wrong folder. Launch the game directly from its installation directory (usually steamapps\common\Resident Evil 6 ). If the game crashes before the main menu,
Ensure you have the latest DirectX End-User Runtimes and Visual C++ Redistributables installed. Advanced Troubleshooting resident evil 6 fatal error failed open file
Does the error message mention a or folder name ?