This usually means the baud rate (for serial connections) or the emulation mode is incorrect. Ensure your driver is set to standard ESC/POS mode.
If your cash drawer plugs directly into the back of the receipt printer via an RJ11/RJ12 cable (looking like a telephone wire), the printer controls when it opens. random data receipt printer driver software v8.2
What are you using to connect it (USB, Network, or Bluetooth)? This usually means the baud rate (for serial